This is probably a better place than the combine thread for this post.
With Smith and Higgins out of consideration, here is my ideal scenario:

Cut/trade Bosa, Pipkins, Edwards
Extend Slater
Re-sign Mack, Ford, Tart, Dobbins, Bozeman, Dye, Heinicke, Scott, Fisk, Smartt, Sarell, Jefferson, Niemann, Stick

Final 53 man roster spots are not guaranteedd for Fisk, Smartt, Sarell, Jefferson, or Niemann; they have to battle for those spots
Jefferson probably would not make the initial 53 man roster to avoid guaranteeing his salary for the season, but would be re-signed after being waived
Stick is planned for the practice squad, not the final 53

Sign C Kelly, RG Fries, OL Mekari, WR Adams (assuming he is cut), and a veteran starting outside CB

CB could be Fulton, but there are others I prefer

That puts them going into the draft in need of (in rough priority order):

Edge – 1st round pick
TE – a 1a/1b to pair with Dissly; rounds 2-4
IDL – ideally a strong pass rusher; rounds 2-4
RB – a 1a/1b to pair with Dobbins; rounds 2-4
Depth at LB, DB, WR, maybe OL

It is very achievable to fill all of those needs in this draft and very achievable to do all of this with cap room to spare.
That could lead to this roster breakdown:

Offense (26):

QB (2) – Herbert, Heinicke (and Stick on practice squad)
RB (4) – Dobbins, TBD rookie, Vidal, Haskins
FB (1) – Matlock (ugh)
WR (6) – Adams, McConkey, Johnston, Rice, TBD rookie, Davis
TE (4) – Dissly, TBD rookie, Fisk, Smartt
OL (9) – LT Slater, LG Mekari/Johnson, C Kelly, RG Fries, RT Alt, G Mekari/Johnson, C Bozeman, OL Salyer, OT Sarell/TBD rookie

Bozeman is quality IOL backup and provides insurance against Kelly injury
Mekari and Zion battle for LG starting spot, and the loser becomes top backup G
OL benefits from chemistry Kelly and Fries already have together

Defense (24):

Edge (4) – Mack, TBD rookie (1st rounder so should be quality starter), Tuli, Dupree
IDL (5) – Ford, Tart, TBD rookie, Ogbonnia, Eboigbe
LB (5) – Henley, Colson, Dye, Niemann/TBD rookie, TBD rookie
CB (6) – TBD veteran free agent, Still, Hart, Leonard, Taylor, TBD rookie
S (4) – James, Gilman, Molden, Jefferson

Special Teams (3):

PK (1) – Dicker
P (1) – Scott
LS (1) – Harris

On offense, this improves OL, passing game, and running game. On defense, this could improve the pass rush while maintaining strong run defense and coverage.
That is a contending roster if Hortiz drafts well and they stay reasonably healthy.